Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Histone arginine demethylase JMJD6 Protein
Recombinant Histone arginine demethylase JMJD6 Protein Cat#
PA0839
Histone arginine demethylase JMJD6 Protein Source
Recombinant protein.
Recombinant Histone arginine demethylase JMJD6 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Histone arginine demethylase JMJD6 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Histone arginine demethylase JMJD6 Protein Activity
N/A
Recombinant protein Tag
Recombinant Histone arginine demethylase JMJD6 Contains A 6x histidine tag
Recombinant Histone arginine demethylase JMJD6 Protein Formulation
Liquid
Recombinant Histone arginine demethylase JMJD6 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Histone arginine demethylase JMJD6 Protein or cDNA
Histone arginine demethylase JMJD6 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a
regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to
bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute
the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by
regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses (By similarity).
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
