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Mouse Kpna1 (aa 1-538)

Kpna1 Swiss Prot#

Q60960

Kpna1 Protein names

Importin subunit alpha-1 (Karyopherin subunit alpha-1) (SRP1-beta) (RAG

cohort protein 2) (Nucleoprotein interactor 1) (Importin alpha S1)

Kpna1 Gene names

Kpna1 (Rch2)

Organism

Mus musculus (Mouse)

Kpna1 Entry name

IMA1_MOUSE

Kpna1 Codon optimized cDNA Clone

Kpna1 CDNA Cat#

RPM0316

cDNA Tag

cDNA Kpna1 Contains A 6x histidine tag

Condon optimized Kpna1 CDNA Formulation

Liquid

Condon optimized Kpna1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized Kpna1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Kpna1 Protein

Recombinant Kpna1 Protein Cat#

PM0316

Kpna1 Protein Source

Recombinant protein.

Recombinant Kpna1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant Kpna1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant Kpna1 Protein Activity

N/A

Recombinant protein Tag

Recombinant Kpna1 contains A 6x histidine tag

Recombinant Kpna1 Protein Formulation

Liquid

Recombinant Kpna1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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Kpna1 Protein family

Importin alpha family

Kpna1 Subcellular locations

Cytoplasm. Nucleus.

Kpna1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Functions in nuclear protein import as an adapter protein for

nuclear receptor KPNB1. Binds specifically and directly to substrates

containing either a simple or bipartite NLS motif. Docking of the

importin/substrate complex to the nuclear pore complex (NPC) is mediated

by KPNB1 through binding to nucleoporin FxFG repeats and the complex is

subsequently translocated through the pore by an energy requiring, Ran-

dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to

importin-beta and the three components separate and importin-alpha and -

beta are re-exported from the nucleus to the cytoplasm where GTP

hydrolysis releases Ran from importin. The directionality of nuclear import is

thought to be conferred by an asymmetric distribution of the GTP- and GDP-

bound forms of Ran between the cytoplasm and nucleus.

Kpna1 Sequence databases

EMBL

DDBJ

GenBank

Kpna1 3D structure databases

ModBase

Kpna1 Protein-protein interaction databases

STRING

Kpna1 Proteomic databases

PRIDE

Kpna1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

Kpna1 Organism specific databases

CTD

MGI

Kpna1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Kpna1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

Kpna1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY