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Magnetic Beads Separator
Magnetic Beads and Applications
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Mouse Itgb3bp (aa 1-176)
Itgb3bp Swiss Prot#
Q9CQ82
Itgb3bp Protein names
Centromere protein R (CENP-R) (Nuclear receptor-interacting factor 3)
Itgb3bp Gene names
Itgb3bp (Cenpr) (Nrif3)
Organism
Mus musculus (Mouse)
Itgb3bp Entry name
CENPR_MOUSE
Itgb3bp Codon optimized cDNA Clone
Itgb3bp CDNA Cat#
RPM0394
cDNA Tag
cDNA Itgb3bp Contains A 6x histidine tag
Condon optimized Itgb3bp CDNA Formulation
Liquid
Condon optimized Itgb3bp CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Itgb3bp cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Itgb3bp Protein
Recombinant Itgb3bp Protein Cat#
PM0394
Itgb3bp Protein Source
Recombinant protein.
Recombinant Itgb3bp Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Itgb3bp Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Itgb3bp Protein Activity
N/A
Recombinant protein Tag
Recombinant Itgb3bp contains A 6x histidine tag
Recombinant Itgb3bp Protein Formulation
Liquid
Recombinant Itgb3bp Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Place Order for Recombinant Itgb3bp Protein or cDNA
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Itgb3bp Protein family
-
Itgb3bp Subcellular locations
Nucleus. Chromosome > centromere.
Itgb3bp FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transcription coregulator that can have both coactivator and

corepressor functions. Involved in the coactivation of nuclear receptors for

retinoid X (RXRs) and thyroid hormone (TRs) in a ligandependent fashion.

In contrast, it does not coactivate nuclear receptors for retinoic acid,

vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator

for estrogen receptor alpha. Acts as a transcriptional corepressor via its

interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with

the transactivation domain of NFKB1. Induces apoptosis in breast cancer

cells, but not in other cancer cells, via a caspase-2 mediated pathway that

involves mitochondrial membrane permeabilization but does not require

other caspases. May also act as an inhibitor of cyclin A-associated kinase.

Also acts a component of the CENPA-CAD (nucleosome distal) complex, a

complex recruited to centromeres which is involved in assembly of

kinetochore proteins, mitotic progression and chromosome segregation.

May be involved in incorporation of newly synthesized CENPA into

centromeres via its interaction with the CENPA-NAC complex (By similarity).
Itgb3bp Sequence databases
EMBL DDBJ GenBank
Itgb3bp 3D structure databases
ModBase
Itgb3bp Protein-protein interaction databases
STRING
Itgb3bp Proteomic databases
PRIDE
Itgb3bp Genome annotation databases
Ensembl GeneID KEGG UCSC
Itgb3bp Organism specific databases
CTD MGI
Itgb3bp Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Itgb3bp Gene expression databases
Bgee ArrayExpress Genevestigator
Itgb3bp Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY