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Magnetic Beads Separator
Magnetic Beads and Applications
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Mouse Dkk3 (aa 23-349)
Dkk3 Swiss Prot#
Q9QUN9
Dkk3 Protein names
Dickkopf-related protein 3 (Dickkopf-3) (Dkk-3) (mDkk-3)
Dkk3 Gene names
Dkk3
Organism
Mus musculus (Mouse)
Dkk3 Entry name
DKK3_MOUSE
Dkk3 Codon optimized cDNA Clone
Dkk3 CDNA Cat#
RPM0422
cDNA Tag
cDNA Dkk3 Contains A 6x histidine tag
Condon optimized Dkk3 CDNA Formulation
Liquid
Condon optimized Dkk3 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Dkk3 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Dkk3 Protein
Recombinant Dkk3 Protein Cat#
PM0422
Dkk3 Protein Source
Recombinant protein.
Recombinant Dkk3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Dkk3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Dkk3 Protein Activity
N/A
Recombinant protein Tag
Recombinant Dkk3 contains A 6x histidine tag
Recombinant Dkk3 Protein Formulation
Liquid
Recombinant Dkk3 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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Dkk3 Protein family
Dickkopf family
Dkk3 Subcellular locations
Secreted.
Dkk3 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6

interaction with Wnt and by forming a ternary complex with the

transmembrane protein KREMEN that promotes internalization of LRP5/6.

DKKs play an important role in vertebrate development, where they locally

inhibit Wnt regulated processes such as antero-posterior axial patterning,

limb development, somitogenesis and eye formation. In the adult, Dkks are

implicated in bone formation and bone disease, cancer and Alzheimer's

disease (By similarity).
Dkk3 Sequence databases
EMBL DDBJ GenBank
Dkk3 3D structure databases
ModBase
Dkk3 Protein-protein interaction databases
STRING
Dkk3 Proteomic databases
PRIDE
Dkk3 Genome annotation databases
Ensembl GeneID KEGG UCSC
Dkk3 Organism specific databases
CTD MGI
Dkk3 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Dkk3 Gene expression databases
Bgee ArrayExpress Genevestigator
Dkk3 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY