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Human COPS2 (aa 1-443)

COPS2 Swiss Prot#

P61201

COPS2 Protein names

COP9 signalosome complex subunit 2 (Signalosome subunit 2) (SGN2)

(JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting

protein 15) (TRIP-15) (Alien homolog)

COPS2 Gene names

COPS2 (CSN2) (TRIP15)

Organism

Homo sapiens (Human)

COPS2 Entry name

CSN2_HUMAN

COPS2 Codon optimized cDNA Clone

COPS2 CDNA Cat#

RPM0059

cDNA Tag

cDNA COPS2 Contains A 6x histidine tag

Condon optimized COPS2 CDNA Formulation

Liquid

Condon optimized COPS2 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized COPS2 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant COPS2 Protein

Recombinant COPS2 Protein Cat#

PM0059

COPS2 Protein Source

Recombinant protein.

Recombinant COPS2 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant COPS2 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant COPS2 Protein Activity

N/A

Recombinant protein Tag

Recombinant COPS2 contains A 6x histidine tag

Recombinant COPS2 Protein Formulation

Liquid

Recombinant COPS2 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

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COPS2 Protein family

CSN2 family

COPS2 Subcellular locations

Cytoplasm. Nucleus.

COPS2 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: Essential component of the COP9 signalosome complex (CSN),

a complex involved in various cellular and developmental processes. The

CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation

pathway by mediating the deneddylation of the cullin subunits of SCF-type E3

ligase complexes, leading to decrease the Ubl ligase activity of SCF-type

complexes such as SCF, CSA or DDB2. The complex is also involved in

phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and

IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-

dependent phosphorylation of TP53 and JUN promotes and protects

degradation by the Ubl system, respectively. Involved in early stage of

neuronal differentiation via its interaction with NIF3L1.

COPS2 Sequence databases

EMBL

DDBJ

GenBank

COPS2 3D structure databases

ModBase

COPS2 Protein-protein interaction databases

STRING

COPS2 Proteomic databases

PRIDE

COPS2 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

COPS2 Organism specific databases

CTD

MGI

COPS2 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

COPS2 Gene expression databases

Bgee

ArrayExpress

Genevestigator

COPS2 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY