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Magnetic Beads Separator
Magnetic Beads and Applications
Affinity Magnetic Beads
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Human SUFU (aa 1-484)
SUFU Swiss Prot#
Q9UMX1
SUFU Protein names
Suppressor of fused homolog (SUFUH)
SUFU Gene names
SUFU (UNQ650/PRO1280)
Organism
Homo sapiens (Human)
SUFU Entry name
SUFU_HUMAN
SUFU Codon optimized cDNA Clone
SUFU CDNA Cat#
RPM0063
cDNA Tag
cDNA SUFU Contains A 6x histidine tag
Condon optimized SUFU CDNA Formulation
Liquid
Condon optimized SUFU CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized SUFU cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant SUFU Protein
Recombinant SUFU Protein Cat#
PM0063
SUFU Protein Source
Recombinant protein.
Recombinant SUFU Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SUFU Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SUFU Protein Activity
N/A
Recombinant protein Tag
Recombinant SUFU contains A 6x histidine tag
Recombinant SUFU Protein Formulation
Liquid
Recombinant SUFU Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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SUFU Protein family
SUFU family
SUFU Subcellular locations
Cytoplasm. Nucleus.
SUFU FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Negative regulator in the hedgehog signaling pathway. Down-

regulates GLI1-mediated transactivation of target genes. Part of a

corepressor complex that acts on DNA-bound GLI1. May also act by linking

GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome.

Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by

binding of STK36 to both SUFU and a GLI protein. Negative regulator of

beta-catenin signaling. Regulates the formation of either the repressor form

(GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL).

GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a

neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to

cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh

signaling is initiated, SUFU dissociates from GLI3FL and the latter

translocates to the nucleus, where it is phosphorylated, destabilized, and

converted to a transcriptional activator (GLI3A).
SUFU Sequence databases
EMBL DDBJ GenBank
SUFU 3D structure databases
ModBase
SUFU Protein-protein interaction databases
STRING
SUFU Proteomic databases
PRIDE
SUFU Genome annotation databases
Ensembl GeneID KEGG UCSC
SUFU Organism specific databases
CTD MGI
SUFU Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
SUFU Gene expression databases
Bgee ArrayExpress Genevestigator
SUFU Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY