Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to
restore the loss-of-function.
Recombinant Retinoic acid receptor RXR-alpha Protein
Recombinant Retinoic acid receptor RXR-alpha Protein Cat#
PW0249
Retinoic acid receptor RXR-alpha Protein Source
Recombinant protein.
Recombinant Retinoic acid receptor RXR-alpha Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Retinoic acid receptor RXR-alpha Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Retinoic acid receptor RXR-alpha Protein Activity
N/A
Recombinant protein Tag
Recombinant Retinoic acid receptor RXR-alpha Contains A 6x histidine tag
Recombinant Retinoic acid receptor RXR-alpha Protein Formulation
Liquid
Recombinant Retinoic acid receptor RXR-alpha Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Retinoic acid receptor RXR-alpha Protein or cDNA
Retinoic acid receptor RXR-alpha FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
