Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to
restore the loss-of-function.
Recombinant TNF receptor-associated factor 2 Protein
Recombinant TNF receptor-associated factor 2 Protein Cat#
PW0262
TNF receptor-associated factor 2 Protein Source
Recombinant protein.
Recombinant TNF receptor-associated factor 2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant TNF receptor-associated factor 2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant TNF receptor-associated factor 2 Protein Activity
N/A
Recombinant protein Tag
Recombinant TNF receptor-associated factor 2 Contains A 6x histidine tag
Recombinant TNF receptor-associated factor 2 Protein Formulation
Liquid
Recombinant TNF receptor-associated factor 2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant TNF receptor-associated factor 2 Protein or cDNA
TNF receptor-associated factor 2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity.
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
