Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to
restore the loss-of-function.
Recombinant Importin subunit alpha-7 Protein
Recombinant Importin subunit alpha-7 Protein Cat#
PW0277
Importin subunit alpha-7 Protein Source
Recombinant protein.
Recombinant Importin subunit alpha-7 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Importin subunit alpha-7 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Importin subunit alpha-7 Protein Activity
N/A
Recombinant protein Tag
Recombinant Importin subunit alpha-7 Contains A 6x histidine tag
Recombinant Importin subunit alpha-7 Protein Formulation
Liquid
Recombinant Importin subunit alpha-7 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Importin subunit alpha-7 Protein or cDNA
Importin subunit alpha-7 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
