SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
SHC-transforming protein 1 Gene names
Shc1 (Shc) (ShcA)
Organism
Mouse
SHC-transforming protein 1 Entry name
SHC1_MOUSE
SHC-transforming protein 1 Codon optimized cDNA Clone
SHC-transforming protein 1 CDNA Cat#
RPW0289
cDNA Tag
cDNA SHC-transforming protein 1 Contains A 6x histidine tag
Condon optimized SHC-transforming protein 1 CDNA Formulation
Liquid
Condon optimized SHC-transforming protein 1 cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized SHC-transforming protein 1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to
restore the loss-of-function.
Recombinant SHC-transforming protein 1 Protein
Recombinant SHC-transforming protein 1 Protein Cat#
PW0289
SHC-transforming protein 1 Protein Source
Recombinant protein.
Recombinant SHC-transforming protein 1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant SHC-transforming protein 1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant SHC-transforming protein 1 Protein Activity
N/A
Recombinant protein Tag
Recombinant SHC-transforming protein 1 Contains A 6x histidine tag
Recombinant SHC-transforming protein 1 Protein Formulation
Liquid
Recombinant SHC-transforming protein 1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant SHC-transforming protein 1 Protein or cDNA
SHC-transforming protein 1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation,
but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-
activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
