Human Parathyroid hormone-related protein (a.a.18–268)
Parathyroid hormone-related protein Swiss Prot#
P12272
Parathyroid hormone-related protein Protein names
Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]
Parathyroid hormone-related protein Gene names
PTHLH PTHRP
Organism
Human
Parathyroid hormone-related protein Entry name
PTHR_HUMAN
Parathyroid hormone-related protein Codon optimized cDNA Clone
Parathyroid hormone-related protein CDNA Cat#
RPA0304
cDNA Tag
cDNA Parathyroid hormone-related protein Contains A 6x histidine tag
Condon optimized Parathyroid hormone-related protein CDNA Formulation
Liquid
Condon optimized Parathyroid hormone-related protein cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized Parathyroid hormone-related protein cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Parathyroid hormone-related protein Protein
Recombinant Parathyroid hormone-related protein Protein Cat#
PA0304
Parathyroid hormone-related protein Protein Source
Recombinant protein.
Recombinant Parathyroid hormone-related protein Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Parathyroid hormone-related protein Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Parathyroid hormone-related protein Protein Activity
N/A
Recombinant protein Tag
Recombinant Parathyroid hormone-related protein Contains A 6x histidine tag
Recombinant Parathyroid hormone-related protein Protein Formulation
Liquid
Recombinant Parathyroid hormone-related protein Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Parathyroid hormone-related protein Protein family
Parathyroid hormone family
Parathyroid hormone-related protein Subcellular locations
Cytoplasm. Nucleus. Secreted.
Parathyroid hormone-related protein FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial- mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs.

Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn,

triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an

integrin alpha-6/beta-1-dependent manner through activation of Rac1.; FUNCTION: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
Parathyroid hormone-related protein Sequence databases
EMBL DDBJ GenBank
Parathyroid hormone-related protein 3D structure databases
ModBase
Parathyroid hormone-related protein Protein-protein interaction databases
STRING
Parathyroid hormone-related protein Proteomic databases
PRIDE
Parathyroid hormone-related protein Genome annotation databases
Ensembl GeneID KEGG UCSC
Parathyroid hormone-related protein Organism specific databases
CTD MGI
Parathyroid hormone-related protein Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Parathyroid hormone-related protein Gene expression databases
Bgee ArrayExpress Genevestigator
Parathyroid hormone-related protein Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY

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