Mouse Cytokine-inducible SH2-containing protein (aa 1-257)
Cytokine-inducible SH2-containing protein Swiss Prot#
Q62225
Cytokine-inducible SH2-containing protein Protein names
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)
Cytokine-inducible SH2-containing protein Gene names
Cish (Cis)
Organism
Mouse
Cytokine-inducible SH2-containing protein Entry name
CISH_MOUSE
Cytokine-inducible SH2-containing protein Codon optimized cDNA Clone
Cytokine-inducible SH2-containing protein CDNA Cat#
RPA0452
cDNA Tag
cDNA Cytokine-inducible SH2-containing protein Contains A 6x histidine tag
Condon optimized Cytokine-inducible SH2-containing protein CDNA Formulation
Liquid
Condon optimized Cytokine-inducible SH2-containing protein cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized Cytokine-inducible SH2-containing protein cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Cytokine-inducible SH2-containing protein Protein
Recombinant Cytokine-inducible SH2-containing protein Protein Cat#
PA0452
Cytokine-inducible SH2-containing protein Protein Source
Recombinant protein.
Recombinant Cytokine-inducible SH2-containing protein Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Cytokine-inducible SH2-containing protein Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Cytokine-inducible SH2-containing protein Protein Activity
N/A
Recombinant protein Tag
Recombinant Cytokine-inducible SH2-containing protein Contains A 6x histidine tag
Recombinant Cytokine-inducible SH2-containing protein Protein Formulation
Liquid
Recombinant Cytokine-inducible SH2-containing protein Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Cytokine-inducible SH2-containing protein Protein or cDNA
Cytokine-inducible SH2-containing protein Protein family
-
Cytokine-inducible SH2-containing protein Subcellular locations
-
Cytokine-inducible SH2-containing protein FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as
erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-
protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Cytokine-inducible SH2-containing protein Sequence databases
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
