Human HLA class II histocompatibility antigen DR alpha (aa 26-216)
HLA class II histocompatibility antigen DR alpha Swiss Prot#
P01903
HLA class II histocompatibility antigen DR alpha Protein names
HLA class II histocompatibility antigen, DR alpha chain (MHC class II antigen DRA)
HLA class II histocompatibility antigen DR alpha Gene names
HLA-DRA (HLA-DRA1)
Organism
Human
HLA class II histocompatibility antigen DR alpha Entry name
DRA_HUMAN
HLA class II histocompatibility antigen DR alpha Codon optimized cDNA Clone
HLA class II histocompatibility antigen DR alpha CDNA Cat#
RPW0047
cDNA Tag
cDNA HLA class II histocompatibility antigen DR alpha Contains A 6x histidine tag
Condon optimized HLA class II histocompatibility antigen DR alpha CDNA Formulation
Liquid
Condon optimized HLA class II histocompatibility antigen DR alpha cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized HLA class II histocompatibility antigen DR alpha cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant HLA class II histocompatibility antigen DR alpha Protein
Recombinant HLA class II histocompatibility antigen DR alpha Protein Cat#
PW0047
HLA class II histocompatibility antigen DR alpha Protein Source
Recombinant protein.
Recombinant HLA class II histocompatibility antigen DR alpha Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant HLA class II histocompatibility antigen DR alpha Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant HLA class II histocompatibility antigen DR alpha Protein Activity
N/A
Recombinant protein Tag
Recombinant HLA class II histocompatibility antigen DR alpha Contains A 6x histidine tag
Recombinant HLA class II histocompatibility antigen DR alpha Protein Formulation
Liquid
Recombinant HLA class II histocompatibility antigen DR alpha Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant HLA class II histocompatibility antigen DR alpha Protein or cDNA
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HLA class II histocompatibility antigen DR alpha Protein family
MHC class II family
HLA class II histocompatibility antigen DR alpha Subcellular locations
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus > trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane pr
HLA class II histocompatibility antigen DR alpha FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal
HLA class II histocompatibility antigen DR alpha Sequence databases
EMBL DDBJ GenBank
HLA class II histocompatibility antigen DR alpha 3D structure databases
ModBase
HLA class II histocompatibility antigen DR alpha Protein-protein interaction databases
STRING
HLA class II histocompatibility antigen DR alpha Proteomic databases
PRIDE
HLA class II histocompatibility antigen DR alpha Genome annotation databases
Ensembl GeneID KEGG UCSC
HLA class II histocompatibility antigen DR alpha Organism specific databases
CTD MGI
HLA class II histocompatibility antigen DR alpha Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
HLA class II histocompatibility antigen DR alpha Gene expression databases
Bgee ArrayExpress Genevestigator
HLA class II histocompatibility antigen DR alpha Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY

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