| Mouse Interleukin-27 subunit alpha (aa 29-234) |
| Interleukin-27 subunit alpha Swiss Prot# |
| Q8K3I6 |
| Interleukin-27 subunit alpha Protein names |
| Interleukin-27 subunit alpha (IL-27 subunit alpha) (IL27-A) (p28) |
| Interleukin-27 subunit alpha Gene names |
| Il27 (Il27a) |
| Interleukin-27 subunit alpha Entry name |
| IL27A_MOUSE |
| Interleukin-27 subunit alpha Codon optimized cDNA Clone |
| Interleukin-27 subunit alpha CDNA Cat# |
| RPA0571 |
| cDNA Tag |
| cDNA Interleukin-27 subunit alpha Contains A 6x histidine tag |
| Condon optimized Interleukin-27 subunit alpha CDNA Formulation |
| Liquid |
| Condon optimized Interleukin-27 subunit alpha cDNA Storage |
| Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized Interleukin-27 subunit alpha cDNA Applications |
| Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Interleukin-27 subunit alpha Protein |
| Recombinant Interleukin-27 subunit alpha Protein Cat# |
| PA0571 |
| Interleukin-27 subunit alpha Protein Source |
| Recombinant protein. |
| Recombinant Interleukin-27 subunit alpha Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Interleukin-27 subunit alpha Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Interleukin-27 subunit alpha Protein Activity |
| N/A |
| Recombinant protein Tag |
| Recombinant Interleukin-27 subunit alpha Contains A 6x histidine tag |
| Recombinant Interleukin-27 subunit alpha Protein Formulation |
| Liquid |
| Recombinant Interleukin-27 subunit alpha Protein Storage |
| Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Interleukin-27 subunit alpha Protein family |
| IL-6 superfamily |
| Interleukin-27 subunit alpha Subcellular locations |
| Secreted. |
| Interleukin-27 subunit alpha FUNCTION (According to UniProtKB/Swiss Prot) |
| FUNCTION: Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects |
on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not |
| memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated |
| signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It |
| also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells |
| development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL-27 subunit p28 alone is also able to inhibit the production of IL17 by CD4 and |
| CD8 T-cells. While IL-27 suppressed the development of proinflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 has also an effect on cytokine |
| production, it suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the |
| effects of some cytokines such as IL6 through direct effects on T cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP- |
| Interleukin-27 subunit alpha 3D structure databases |
| ModBase |
| Interleukin-27 subunit alpha Protein-protein interaction databases |
| STRING |
| Interleukin-27 subunit alpha Proteomic databases |
| PRIDE |
| Interleukin-27 subunit alpha Organism specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY |
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