Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein Cat#
PA0594
Leukocyte-associated immunoglobulin-like 1 Protein Source
Recombinant protein.
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein Activity
N/A
Recombinant protein Tag
Recombinant Leukocyte-associated immunoglobulin-like 1 Contains A 6x histidine tag
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein Formulation
Liquid
Recombinant Leukocyte-associated immunoglobulin-like 1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Leukocyte-associated immunoglobulin-like 1 Protein or cDNA
Cell membrane; Single-pass type I membrane protein.
Leukocyte-associated immunoglobulin-like 1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the
phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-
cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces
apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
