Zinc finger protein Gfi-1b (Growth factor independent protein 1B)
Zinc finger protein Gfi-1b Gene names
Gfi1b
Organism
Mouse
Zinc finger protein Gfi-1b Entry name
GFI1B_MOUSE
Zinc finger protein Gfi-1b Codon optimized cDNA Clone
Zinc finger protein Gfi-1b CDNA Cat#
RPA0729
cDNA Tag
cDNA Zinc finger protein Gfi-1b Contains A 6x histidine tag
Condon optimized Zinc finger protein Gfi-1b CDNA Formulation
Liquid
Condon optimized Zinc finger protein Gfi-1b cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized Zinc finger protein Gfi-1b cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Zinc finger protein Gfi-1b Protein
Recombinant Zinc finger protein Gfi-1b Protein Cat#
PA0729
Zinc finger protein Gfi-1b Protein Source
Recombinant protein.
Recombinant Zinc finger protein Gfi-1b Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Zinc finger protein Gfi-1b Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Zinc finger protein Gfi-1b Protein Activity
N/A
Recombinant protein Tag
Recombinant Zinc finger protein Gfi-1b Contains A 6x histidine tag
Recombinant Zinc finger protein Gfi-1b Protein Formulation
Liquid
Recombinant Zinc finger protein Gfi-1b Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Zinc finger protein Gfi-1b Protein or cDNA
Zinc finger protein Gfi-1b FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Transcriptional repressor or activator depending on both promoter and cell type context;
represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines
markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits
GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated
stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes
promoters. Plays a role in heterochromatin formation.
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
