Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Angiotensinogen Protein
Recombinant Angiotensinogen Protein Cat#
Angiotensinogen Protein Source
Recombinant Angiotensinogen Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Angiotensinogen Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Angiotensinogen Protein Activity
Recombinant protein Tag
Recombinant Angiotensinogen Contains A 6x histidine tag
Recombinant Angiotensinogen Protein Formulation
Recombinant Angiotensinogen Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Angiotensinogen Protein or cDNA
Angiotensinogen FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce
angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1-8). Angiotensin-1 and angiotensin-2 can be
further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by
ACE2.; FUNCTION: Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption
through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; FUNCTION: Angiotensin-3 stimulates aldosterone release.; FUNCTION: Angiotensin 1-7 is a ligand for the G-protein coupled
receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).