Human WW domain-containing transcription regulator 1 (aa 1-400)
WW domain-containing transcription regulator 1 Swiss Prot#
Q9GZV5
WW domain-containing transcription regulator 1 Protein names
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
WW domain-containing transcription regulator 1 Gene names
WWTR1 (TAZ)
Organism
Human
WW domain-containing transcription regulator 1 Entry name
WWTR1_HUMAN
WW domain-containing transcription regulator 1 Codon optimized cDNA Clone
WW domain-containing transcription regulator 1 CDNA Cat#
RPW0090
cDNA Tag
cDNA WW domain-containing transcription regulator 1 Contains A 6x histidine tag
Condon optimized WW domain-containing transcription regulator 1 CDNA Formulation
Liquid
Condon optimized WW domain-containing transcription regulator 1 cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized WW domain-containing transcription regulator 1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant WW domain-containing transcription regulator 1 Protein
Recombinant WW domain-containing transcription regulator 1 Protein Cat#
PW0090
WW domain-containing transcription regulator 1 Protein Source
Recombinant protein.
Recombinant WW domain-containing transcription regulator 1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant WW domain-containing transcription regulator 1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant WW domain-containing transcription regulator 1 Protein Activity
N/A
Recombinant protein Tag
Recombinant WW domain-containing transcription regulator 1 Contains A 6x histidine tag
Recombinant WW domain-containing transcription regulator 1 Protein Formulation
Liquid
Recombinant WW domain-containing transcription regulator 1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant WW domain-containing transcription regulator 1 Protein or cDNA
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WW domain-containing transcription regulator 1 Protein family
-
WW domain-containing transcription regulator 1 Subcellular locations
Nucleus. Cytoplasm.
WW domain-containing transcription regulator 1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and

inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator

complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
WW domain-containing transcription regulator 1 Sequence databases
EMBL DDBJ GenBank
WW domain-containing transcription regulator 1 3D structure databases
ModBase
WW domain-containing transcription regulator 1 Protein-protein interaction databases
STRING
WW domain-containing transcription regulator 1 Proteomic databases
PRIDE
WW domain-containing transcription regulator 1 Genome annotation databases
Ensembl GeneID KEGG UCSC
WW domain-containing transcription regulator 1 Organism specific databases
CTD MGI
WW domain-containing transcription regulator 1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
WW domain-containing transcription regulator 1 Gene expression databases
Bgee ArrayExpress Genevestigator
WW domain-containing transcription regulator 1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY

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