Human Hematopoietic cell signal transducer (aa 19-93)
Hematopoietic cell signal transducer Swiss Prot#
Q9UBK5
Hematopoietic cell signal transducer Protein names
Hematopoietic cell signal transducer (Transmembrane adapter protein KAP10) (DNAX-activation protein 10) (Membrane protein DAP10)
Hematopoietic cell signal transducer Gene names
HCST (DAP10) (KAP10) (PIK3AP) (UNQ587/PRO1157)
Organism
Human
Hematopoietic cell signal transducer Entry name
HCST_HUMAN
Hematopoietic cell signal transducer Codon optimized cDNA Clone
Hematopoietic cell signal transducer CDNA Cat#
RPA0090
cDNA Tag
cDNA Hematopoietic cell signal transducer Contains A 6x histidine tag
Condon optimized Hematopoietic cell signal transducer CDNA Formulation
Liquid
Condon optimized Hematopoietic cell signal transducer cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized Hematopoietic cell signal transducer cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Hematopoietic cell signal transducer Protein
Recombinant Hematopoietic cell signal transducer Protein Cat#
PA0090
Hematopoietic cell signal transducer Protein Source
Recombinant protein.
Recombinant Hematopoietic cell signal transducer Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Hematopoietic cell signal transducer Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Hematopoietic cell signal transducer Protein Activity
N/A
Recombinant protein Tag
Recombinant Hematopoietic cell signal transducer Contains A 6x histidine tag
Recombinant Hematopoietic cell signal transducer Protein Formulation
Liquid
Recombinant Hematopoietic cell signal transducer Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Hematopoietic cell signal transducer Protein or cDNA
Hematopoietic cell signal transducer Protein family
DAP10 family
Hematopoietic cell signal transducer Subcellular locations
Membrane; Single-pass type I membrane protein.
Hematopoietic cell signal transducer FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transmembrane adapter protein which associates with NKG2D to form an activation receptor NKG2D-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell
surface ligands such as MHC class I chain-related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking
site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 triggers calcium mobilization and activation of the PIK3R1, MAP2K/ERK, and JAK2/STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full NKG2D-HCST-
mediated activation and ultimate killing of target cells. In NK cells, NKG2D-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12/TYROBP-associated receptors. In T cells, it provides primarily
costimulation for TCR-induced signals. NKG2D-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells; indeed, melanoma cells that do not express NKG2D ligands escape from immune
surveillance mediated by NK cells.
Hematopoietic cell signal transducer Sequence databases
For cDNA or Recombinant Protein Search ( Input Cat#, or Gene name, or Protein Name, or Accession Number, or the first 60 amino acids sequence from Met)
