Rat Suppressor of cytokine signaling 3 (aa 1-225)
Suppressor of cytokine signaling 3 Swiss Prot#
O88583
Suppressor of cytokine signaling 3 Protein names
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3)
Suppressor of cytokine signaling 3 Gene names
Socs3 (Cish3)
Organism
Rat
Suppressor of cytokine signaling 3 Entry name
SOCS3_RAT
Suppressor of cytokine signaling 3 Codon optimized cDNA Clone
Suppressor of cytokine signaling 3 CDNA Cat#
RPA0926
cDNA Tag
cDNA Suppressor of cytokine signaling 3 Contains A 6x histidine tag
Condon optimized Suppressor of cytokine signaling 3 CDNA Formulation
Liquid
Condon optimized Suppressor of cytokine signaling 3 cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized Suppressor of cytokine signaling 3 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Suppressor of cytokine signaling 3 Protein
Recombinant Suppressor of cytokine signaling 3 Protein Cat#
PA0926
Suppressor of cytokine signaling 3 Protein Source
Recombinant protein.
Recombinant Suppressor of cytokine signaling 3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Suppressor of cytokine signaling 3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Suppressor of cytokine signaling 3 Protein Activity
N/A
Recombinant protein Tag
Recombinant Suppressor of cytokine signaling 3 Contains A 6x histidine tag
Recombinant Suppressor of cytokine signaling 3 Protein Formulation
Liquid
Recombinant Suppressor of cytokine signaling 3 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Suppressor of cytokine signaling 3 Protein or cDNA
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Suppressor of cytokine signaling 3 Protein family
-
Suppressor of cytokine signaling 3 Subcellular locations
-
Suppressor of cytokine signaling 3 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and

maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which

mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Suppressor of cytokine signaling 3 Sequence databases
EMBL DDBJ GenBank
Suppressor of cytokine signaling 3 3D structure databases
ModBase
Suppressor of cytokine signaling 3 Protein-protein interaction databases
STRING
Suppressor of cytokine signaling 3 Proteomic databases
PRIDE
Suppressor of cytokine signaling 3 Genome annotation databases
Ensembl GeneID KEGG UCSC
Suppressor of cytokine signaling 3 Organism specific databases
CTD MGI
Suppressor of cytokine signaling 3 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Suppressor of cytokine signaling 3 Gene expression databases
Bgee ArrayExpress Genevestigator
Suppressor of cytokine signaling 3 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY

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