Human Histone arginine demethylase JMJD6 (aa 1-403)
Histone arginine demethylase JMJD6 Swiss Prot#
Q6NYC1
Histone arginine demethylase JMJD6 Protein names
Histone arginine demethylase JMJD6 (EC 1.14.11.-) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Protein PTDSR) (Phosphatidylserine 1-receptor)
Histone arginine demethylase JMJD6 Gene names
JMJD6 (KIAA0585) (PTDSR)
Organism
Human
Histone arginine demethylase JMJD6 Entry name
JMJD6_HUMAN
Histone arginine demethylase JMJD6 Codon optimized cDNA Clone
Histone arginine demethylase JMJD6 CDNA Cat#
RPA0093
cDNA Tag
cDNA Histone arginine demethylase JMJD6 Contains A 6x histidine tag
Condon optimized Histone arginine demethylase JMJD6 CDNA Formulation
Liquid
Condon optimized Histone arginine demethylase JMJD6 cDNA Storage
Ship at Room temperature.. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Condon optimized Histone arginine demethylase JMJD6 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Histone arginine demethylase JMJD6 Protein
Recombinant Histone arginine demethylase JMJD6 Protein Cat#
PA0093
Histone arginine demethylase JMJD6 Protein Source
Recombinant protein.
Recombinant Histone arginine demethylase JMJD6 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Histone arginine demethylase JMJD6 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Histone arginine demethylase JMJD6 Protein Activity
N/A
Recombinant protein Tag
Recombinant Histone arginine demethylase JMJD6 Contains A 6x histidine tag
Recombinant Histone arginine demethylase JMJD6 Protein Formulation
Liquid
Recombinant Histone arginine demethylase JMJD6 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Place Order for Recombinant Histone arginine demethylase JMJD6 Protein or cDNA
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Histone arginine demethylase JMJD6 Protein family
JMJD6 family
Histone arginine demethylase JMJD6 Subcellular locations
Nucleus > nucleoplasm. Nucleus > nucleolus.
Histone arginine demethylase JMJD6 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to

bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute

the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by

regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
Histone arginine demethylase JMJD6 Sequence databases
EMBL DDBJ GenBank
Histone arginine demethylase JMJD6 3D structure databases
ModBase
Histone arginine demethylase JMJD6 Protein-protein interaction databases
STRING
Histone arginine demethylase JMJD6 Proteomic databases
PRIDE
Histone arginine demethylase JMJD6 Genome annotation databases
Ensembl GeneID KEGG UCSC
Histone arginine demethylase JMJD6 Organism specific databases
CTD MGI
Histone arginine demethylase JMJD6 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Histone arginine demethylase JMJD6 Gene expression databases
Bgee ArrayExpress Genevestigator
Histone arginine demethylase JMJD6 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY

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