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Human LAIR1 (aa 22-287)
LAIR1 Swiss Prot#
Q6GTX8
LAIR1 Protein names
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD

antigen CD305)
LAIR1 Gene names
LAIR1 (CD305)
Organism
Human
LAIR1 Entry name
LAIR1_HUMAN
LAIR1 Codon optimized cDNA Clone
LAIR1 CDNA Cat#
RPT0130
cDNA Tag
cDNA LAIR1 Contains A 6x histidine tag
Condon optimized LAIR1 CDNA Formulation
Liquid
Condon optimized LAIR1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized LAIR1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant LAIR1 Protein
Recombinant LAIR1 Protein Cat#
PT0130
LAIR1 Protein Source
Recombinant protein.
Recombinant LAIR1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant LAIR1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant LAIR1 Protein Activity
N/A
Recombinant protein Tag
Recombinant LAIR1 contains A 6x histidine tag
Recombinant LAIR1 Protein Formulation
Liquid
Recombinant LAIR1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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LAIR1 Protein family
-
LAIR1 Subcellular locations
Cell membrane; Single-pass type I membrane protein.
LAIR1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Functions as an inhibitory receptor that plays a constitutive

negative regulatory role on cytolytic function of natural killer (NK) cells, B-

cells and T-cells. Activation by Tyr phosphorylation results in recruitment

and activation of the phosphatases PTPN6 and PTPN11. It also reduces the

increase of intracellular calcium evoked by B-cell receptor ligation. May

also play its inhibitory role independently of SH2-containing phosphatases.

Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG

production while inducing secretion of transforming growth factor beta.

Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10

and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid

leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B

p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these

cells. Inhibits the differentiation of peripheral blood precursors towards

dendritic cells.
LAIR1 Sequence databases
EMBL DDBJ GenBank
LAIR1 3D structure databases
ModBase
LAIR1 Protein-protein interaction databases
STRING
LAIR1 Proteomic databases
PRIDE
LAIR1 Genome annotation databases
Ensembl GeneID KEGG UCSC
LAIR1 Organism specific databases
CTD MGI
LAIR1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
LAIR1 Gene expression databases
Bgee ArrayExpress Genevestigator
LAIR1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY