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| Human CD148 (aa 119-620) |
| CD148 Swiss Prot | | Q12913 |
| CD148 Protein names | | Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148) |
| CD148 Gene names | | PTPRJ DEP1 |
| Organism | | Human |
| CD148 Entry name | | PTPRJ_HUMAN |
| CD148 Codon optimized cDNA Clone |
| CD148 cDNA Cat | | RPV0163 |
| cDNA Tag | | cDNA CD148 contains A 6x histidine tag |
| Condon optimized CD148 cDNA Formulation | | Liquid |
| Condon optimized CD148 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD148 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD148 Protein |
| Recombinant CD148 Protein Cat | | PV0163 |
| CD148 Protein Source | | Recombinant protein |
| Recombinant CD148 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD148 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD148 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD148 contains A 6x histidine tag |
| Recombinant CD148 Protein Formulation | | Liquid |
| Recombinant CD148 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD148 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD148 SUBUNIT | | SUBUNIT: Monomer. Interacts with CTNNB1 (phosphorylated) and JUP (phosphorylated). Interacts with GAB1 and GRB2. |
| CD148 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane (By similarity). Cell junction. Note=After T cell stimulation, it is temporarily excluded from immunological synapses. |
| CD148 FUNCTION According to UniProtKB Swiss Prot | | Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell |
| | proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative |
| | regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated |
| | and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. |
| CD148 Sequence databases | | EMBL | DDBJ | GenBank |
| CD148 3D structure databases | | ModBase |
| CD148 Protein protein interaction databases | | STRING |
| CD148 Proteomic databases | | PRIDE |
| CD148 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD148 Organism specific databases | | CTD | MGI |
| CD148 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD148 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD148 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
