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| Human cd155 (aa 21 – 343) |
| CD155 Swiss Prot | | P15151 |
| CD155 Protein names | | Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155) |
| CD155 Gene names | | PVR PVS |
| Organism | | Human |
| CD155 Entry name | | PVR_HUMAN |
| CD155 Codon optimized cDNA Clone |
| CD155 cDNA Cat | | RPV0180 |
| cDNA Tag | | cDNA CD155 contains A 6x histidine tag |
| Condon optimized CD155 cDNA Formulation | | Liquid |
| Condon optimized CD155 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD155 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD155 Protein |
| Recombinant CD155 Protein Cat | | PV0180 |
| CD155 Protein Source | | Recombinant protein |
| Recombinant CD155 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD155 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD155 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD155 contains A 6x histidine tag |
| Recombinant CD155 Protein Formulation | | Liquid |
| Recombinant CD155 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD155 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD155 SUBUNIT | | SUBUNIT: Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT. |
| CD155 Subcellular locations | | SUBCELLULAR LOCATION: Isoform Alpha: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform Delta: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform Beta: Secreted. ; SUBCELLULAR LOCATION: Isoform Gamma: Secreted. |
| CD155 FUNCTION According to UniProtKB Swiss Prot | | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. |
| | This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. |
| | Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This |
| | interaction would drive the virus-containing vesicle to the axonal retrograde transport. |
| CD155 Sequence databases | | EMBL | DDBJ | GenBank |
| CD155 3D structure databases | | ModBase |
| CD155 Protein protein interaction databases | | STRING |
| CD155 Proteomic databases | | PRIDE |
| CD155 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD155 Organism specific databases | | CTD | MGI |
| CD155 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD155 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD155 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
