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Human WDR77 (aa 1-342)
WDR77 Swiss Prot#
Q9BQA1
WDR77 Protein names
Methylosome protein 50 (MEP-50) (WD repeat-containing protein 77)

(Androgen receptor cofactor p44) (p44/Mep50)
WDR77 Gene names
WDR77 (MEP50) (HKMT1069) (Nbla10071)
Organism
Human
WDR77 Entry name
MEP50_HUMAN
WDR77 Codon optimized cDNA Clone
WDR77 CDNA Cat#
RPT0195
cDNA Tag
cDNA WDR77 Contains A 6x histidine tag
Condon optimized WDR77 CDNA Formulation
Liquid
Condon optimized WDR77 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized WDR77 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant WDR77 Protein
Recombinant WDR77 Protein Cat#
PT0195
WDR77 Protein Source
Recombinant protein.
Recombinant WDR77 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant WDR77 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant WDR77 Protein Activity
N/A
Recombinant protein Tag
Recombinant WDR77 contains A 6x histidine tag
Recombinant WDR77 Protein Formulation
Liquid
Recombinant WDR77 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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WDR77 Protein family
-
WDR77 Subcellular locations
Nucleus. Cytoplasm.
WDR77 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Non-catalytic component of the 20S PRMT5-containing

methyltransferase complex, which modifies specific arginines to

dimethylarginines in several spliceosomal Sm proteins. This modification

targets Sm proteins to the survival of motor neurons (SMN) complex for

assembly into small nuclear ribonucleoprotein core particles. Might play a

role in transcription regulation. The 20S PRMT5-containing

methyltransferase complex also methylates the Piwi proteins (PIWIL1,

PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the

interaction with Tudor domain-containing proteins and subsequent

localization to the meiotic nuage.
WDR77 Sequence databases
EMBL DDBJ GenBank
WDR77 3D structure databases
ModBase
WDR77 Protein-protein interaction databases
STRING
WDR77 Proteomic databases
PRIDE
WDR77 Genome annotation databases
Ensembl GeneID KEGG UCSC
WDR77 Organism specific databases
CTD MGI
WDR77 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
WDR77 Gene expression databases
Bgee ArrayExpress Genevestigator
WDR77 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY