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Magnetic Separator
Magnetic Beads and Applications
Affinity Magnetic Beads
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Reversed-Phase  Beads
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Ion Exchange Beads
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Antibody Purification & IP
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Antibody Immobilization
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Recombinant Protein
Purification
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Peptide Immobilization
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Mouse Casp8 (aa 1-480)
Casp8 Swiss Prot#
O89110
Casp8 Protein names
Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18;

Caspase-8 subunit p10]
Casp8 Gene names
Casp8
Organism
Mouse
Casp8 Entry name
CASP8_MOUSE
Casp8 Codon optimized cDNA Clone
Casp8 CDNA Cat#
RPR0205
cDNA Tag
cDNA Casp8 Contains A 6x histidine tag
Condon optimized Casp8 CDNA Formulation
Liquid
Condon optimized Casp8 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Casp8 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Casp8 Protein
Recombinant Casp8 Protein Cat#
PR0205
Casp8 Protein Source
Recombinant protein.
Recombinant Casp8 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Casp8 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Casp8 Protein Activity
N/A
Recombinant protein Tag
Recombinant Casp8 contains A 6x histidine tag
Recombinant Casp8 Protein Formulation
Liquid
Recombinant Casp8 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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Casp8 Protein family
Peptidase C14A family
Casp8 Subcellular locations
-
Casp8 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Most upstream protease of the activation cascade of caspases

responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell

death. Binding to the adapter molecule FADD recruits it to either receptor.

The resulting aggregate called death-inducing signaling complex (DISC)

performs CASP8 proteolytic activation. The active dimeric enzyme is then

liberated from the DISC and free to activate downstream apoptotic

proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3,

CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates

CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in

the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-

molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox

virus CRMA death inhibitory protein.
Casp8 Sequence databases
EMBL DDBJ GenBank
Casp8 3D structure databases
ModBase
Casp8 Protein-protein interaction databases
STRING
Casp8 Proteomic databases
PRIDE
Casp8 Genome annotation databases
Ensembl GeneID KEGG UCSC
Casp8 Organism specific databases
CTD MGI
Casp8 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Casp8 Gene expression databases
Bgee ArrayExpress Genevestigator
Casp8 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY