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Mouse Foxa2 (aa 1-459)
Foxa2 Swiss Prot#
P35583
Foxa2 Protein names
Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box

protein A2)
Foxa2 Gene names
Foxa2 (Hnf3b) (Tcf-3b) (Tcf3b)
Organism
Mouse
Foxa2 Entry name
FOXA2_MOUSE
Foxa2 Codon optimized cDNA Clone
Foxa2 CDNA Cat#
RPU0209
cDNA Tag
cDNA Foxa2 Contains A 6x histidine tag
Condon optimized Foxa2 CDNA Formulation
Liquid
Condon optimized Foxa2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Foxa2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Foxa2 Protein
Recombinant Foxa2 Protein Cat#
PU0209
Foxa2 Protein Source
Recombinant protein.
Recombinant Foxa2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Foxa2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Foxa2 Protein Activity
N/A
Recombinant protein Tag
Recombinant Foxa2 contains A 6x histidine tag
Recombinant Foxa2 Protein Formulation
Liquid
Recombinant Foxa2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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Foxa2 Protein family
-
Foxa2 Subcellular locations
Nucleus. Cytoplasm.
Foxa2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Transcription factor that is involved in embryonic development,

establishment of tissue-specific gene expression and regulation of gene

expression in differentiated tissues. Is thought to act as a 'pioneer' factor

opening the compacted chromatin for other proteins through interactions

with nucleosomal core histones and thereby replacing linker histones at

target enhancer and/or promoter sites. Binds DNA with the consensus

sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic

development is required for notochord formation. Involved in the

development of multiple endoderm-derived organ systems such as the

liver, pancreas and lungs; Foxa1 and Foxa2 seem to have at least in part

redundant roles. FOXA1 and FOXA2 are essential for hepatic specification.

FOXA1 and FOXA2 are required for morphogenesis and cell differentiation

during formation of the lung. FOXA1 and FOXA2 are involved in bile duct

formation; they positively regulate the binding glucocorticoid

receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple

phases of midbrain dopaminergic neuron development; they regulate

expression of NEUROG2 at the beginning of mDA neurogenesis and of

NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional

activity of nuclear hormone receptors; inhibits AR-mediated transcription

from the LCN5 promoter. Binds to fibrinogen beta promoter and is involved

in IL6-induced fibrinogen beta transcriptional activation. Originally discribed

as a transcription activator for a number of liver genes such as AFP,

albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-

acting regulatory regions of these genes. Involved in glucose homeostasis;

regulates the expression of genes important for glucose sensing in

pancreatic beta-cells and glucose homeostasis. In pancratic beta cells

activates transcription of potassium channel subunits KCNJ11 and ABCC8.

Involved in regulation of fat metabolism; activates transcriptional

programs of lipid metabolism and ketogenesis at low insulin state. Involved

in transcriptional regulation of MUC2 in the intestine.
Foxa2 Sequence databases
EMBL DDBJ GenBank
Foxa2 3D structure databases
ModBase
Foxa2 Protein-protein interaction databases
STRING
Foxa2 Proteomic databases
PRIDE
Foxa2 Genome annotation databases
Ensembl GeneID KEGG UCSC
Foxa2 Organism specific databases
CTD MGI