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Magnetic Separator
Magnetic Beads and Applications
Affinity Magnetic Beads
  • Amine-d
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Reversed-Phase  Beads
  • C4
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Ion Exchange Beads
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Antibody Purification & IP
  • Protein A
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Antibody Immobilization
  • Protein A
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Recombinant Protein
Purification
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Peptide Immobilization
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Immobilization
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  • For cDNA or Recombinant Protein Search ( Input Cat#,
    or Gene name, or Protein Name, or Accession Number
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Mouse Lin28 (aa 1-209)
Lin28 Swiss Prot#
Q8K3Y3
Lin28 Protein names
Lin-28 homolog A (Testis-expressed protein 17)
Lin28 Gene names
Lin28 (Lin28a) (Tex17)
Organism
Mouse
Lin28 Entry name
LN28A_MOUSE
Lin28 Codon optimized cDNA Clone
Lin28 CDNA Cat#
RPU0240
cDNA Tag
cDNA Lin28 Contains A 6x histidine tag
Condon optimized Lin28 CDNA Formulation
Liquid
Condon optimized Lin28 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Lin28 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Lin28 Protein
Recombinant Lin28 Protein Cat#
PU0240
Lin28 Protein Source
Recombinant protein.
Recombinant Lin28 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Lin28 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Lin28 Protein Activity
N/A
Recombinant protein Tag
Recombinant Lin28 contains A 6x histidine tag
Recombinant Lin28 Protein Formulation
Liquid
Recombinant Lin28 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Place Order for Recombinant Lin28 Protein or cDNA
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Lin28 Protein family
Lin-28 family
Lin28 Subcellular locations
Cytoplasm. Nucleus > nucleolus.
Lin28 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Acts as a 'translational enhancer', driving specific mRNAs to

polysomes and thus increasing the efficiency of protein synthesis. Its

association with the translational machinery and target mRNAs results in an

increased number of initiation events per molecule of mRNA and,

indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA,

ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for

skeletal muscle differentiation program through the translational up-

regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA)

biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA

precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4

uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated

pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation.

Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the

maintenance of ES cells. In contrast, Lin28a down-regulation in neural stem

cells by miR-125, allows the processing of pre-let-7. Specifically recognizes

the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and

binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the

terminal loop, leading to their terminal uridylation and subsequent

degradation.
Lin28 Sequence databases
EMBL DDBJ GenBank
Lin28 3D structure databases
ModBase
Lin28 Protein-protein interaction databases
STRING
Lin28 Proteomic databases
PRIDE
Lin28 Genome annotation databases
Ensembl GeneID KEGG UCSC
Lin28 Organism specific databases
CTD MGI
Lin28 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Lin28 Gene expression databases
Bgee ArrayExpress Genevestigator
Lin28 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY