| PTEN Protein names |
| Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity |
| protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) |
| (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1) |
| PTEN Gene names |
| PTEN (MMAC1) (TEP1) |
| PTEN Entry name |
| PTEN_HUMAN |
| PTEN Codon optimized cDNA Clone |
| cDNA Tag |
| cDNA PTEN Contains A 6x histidine tag |
| Condon optimized PTEN CDNA Formulation |
| Liquid |
| Condon optimized PTEN CDNA Storage |
| Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw |
| Condon optimized PTEN cDNA Applications |
| Applications: 1. Codon-optimized cDNA sequence designed for recombinant |
| protein production in both E.coli and Mammalian cell. The cDNA has been |
| cloned into E.coli expression vector with 6x Histidine tag.2. May be used as |
| RNAi assistance to restore the loss-of-function. |
| Recombinant PTEN Protein Cat# |
| PT0249 |
| PTEN Protein Source |
| Recombinant protein. |
| Recombinant PTEN Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant PTEN Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant PTEN Protein Activity |
| N/A |
| Recombinant protein Tag |
| Recombinant PTEN contains A 6x histidine tag |
| Recombinant PTEN Protein Formulation |
| Liquid |
| Recombinant PTEN Protein Storage |
| Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw |
| PTEN Subcellular locations |
| Cytoplasm. Nucleus. Nucleus > PML body. |
| PTEN FUNCTION (According to UniProtKB/Swiss Prot) |
| FUNCTION: Tumor suppressor. Acts as a dual-specificity protein |
| phosphatase, dephosphorylating tyrosine-, serine- and threonine- |
| phosphorylated proteins. Also acts as a lipid phosphatase, removing the |
| phosphate in the D3 position of the inositol ring from phosphatidylinositol |
| 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, |
| phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with |
| order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > |
| PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its |
| tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling |
| pathway by dephosphorylating phosphoinositides and thereby modulating |
| cell cycle progression and cell survival. The unphosphorylated form |
| cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates |
| tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration |
| and integrin-mediated cell spreading and focal adhesion formation. Plays a |
| role as a key modulator of the AKT-mTOR signaling pathway controlling the |
| tempo of the process of newborn neurons integration during adult |
| neurogenesis, including correct neuron positioning, dendritic development |
| and synapse formation. May be a negative regulator of insulin signaling and |
| glucose metabolism in adipose tissue. The nuclear monoubiquitinated form |
| possesses greater apoptotic potential, whereas the cytoplasmic |
| nonubiquitinated form induces less tumor suppressive ability. |
| PTEN 3D structure databases |
| ModBase |
| PTEN Protein-protein interaction databases |
| STRING |
| PTEN Proteomic databases |
| PRIDE |
| PTEN Organism specific databases |
| CTD |
MGI |
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