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| Rat cd184 (extracellular domain fused GFP at C-terminal) |
| CD184 Swiss Prot | | O08565 |
| CD184 Protein names | | C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184) |
| CD184 Gene names | | Cxcr4 Cmkar4 |
| Organism | | Rat |
| CD184 Entry name | | CXCR4_RAT |
| CD184 Codon optimized cDNA Clone |
| CD184 cDNA Cat | | RPV0284 |
| cDNA Tag | | cDNA CD184 contains A 6x histidine tag |
| Condon optimized CD184 cDNA Formulation | | Liquid |
| Condon optimized CD184 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD184 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD184 Protein |
| Recombinant CD184 Protein Cat | | PV0284 |
| CD184 Protein Source | | Recombinant protein |
| Recombinant CD184 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD184 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD184 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD184 contains A 6x histidine tag |
| Recombinant CD184 Protein Formulation | | Liquid |
| Recombinant CD184 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD184 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD184 SUBUNIT | | SUBUNIT: Monomer (By similarity). Can form dimers (By similarity). Interacts with CD164. Interacts with ARRB2; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with ARRC; the interaction is dependent on the C-terminal phosphorylation of CXCR4 and modulates calcium mobilization. Interacts (via the cytoplasmic C-terminal) with ITCH (via the WW domains I and II); the interaction, enhanced by CXCL12, |
| | ubiquitinates CXCR4 and leads to its degradation. Interacts with extracellular ubiquitin; the interaction enhances intracellular calcium ions and reduces cellular cAMP levels (By similarity). |
| CD184 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated (By similarity). |
| CD184 FUNCTION According to UniProtKB Swiss Prot | | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or |
| | remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). |
| CD184 Sequence databases | | EMBL | DDBJ | GenBank |
| CD184 3D structure databases | | ModBase |
| CD184 Protein protein interaction databases | | STRING |
| CD184 Proteomic databases | | PRIDE |
| CD184 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD184 Organism specific databases | | CTD | MGI |
| CD184 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD184 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD184 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
