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Mouse Runx1 (aa 1-451)

Runx1 Swiss Prot#

Q03347

Runx1 Protein names

Runt-related transcription factor 1 (Core-binding factor subunit alpha-2)

(CBF-alpha-2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1)

(Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B)

(PEA2-alpha B) (SL3-3 enhancer factor 1 a

Runx1 Gene names

Runx1 (Aml1) (Cbfa2) (Pebp2ab)

Organism

Mouse

Runx1 Entry name

RUNX1_MOUSE

Runx1 Codon optimized cDNA Clone

Runx1 CDNA Cat#

RPU0315

cDNA Tag

cDNA Runx1 Contains A 6x histidine tag

Condon optimized Runx1 CDNA Formulation

Liquid

Condon optimized Runx1 CDNA Storage

Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Condon optimized Runx1 cDNA Applications

Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Runx1 Protein

Recombinant Runx1 Protein Cat#

PU0315

Runx1 Protein Source

Recombinant protein.

Recombinant Runx1 Protein Applications

Western Blot, may be used for other applications determined by user

Recombinant Runx1 Protein Purity

>90%, as determined by SDS-PAGE under reducing conditions

Recombinant Runx1 Protein Activity

N/A

Recombinant protein Tag

Recombinant Runx1 contains A 6x histidine tag

Recombinant Runx1 Protein Formulation

Liquid

Recombinant Runx1 Protein Storage

Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw

Place Order for Recombinant Runx1 Protein or cDNA

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Runx1 Protein family

Runx1 Subcellular locations

Nucleus.

Runx1 FUNCTION (According to UniProtKB/Swiss Prot)

FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of

enhancers and promoters, including murine leukemia virus, polyomavirus

enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters.

Essential for the development of normal hematopoiesis. Isoform 4 shows

higher binding activities for target genes and binds TCR-beta-E2 and RAG-1

target site with threefold higher affinity than other isoforms. It is less

effective in the context of neutrophil terminal differentiation. Acts

synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to

transactivate the BLK promoter. Inhibits MYST4-dependent transcriptional

activation (By similarity).

Runx1 Sequence databases

EMBL

DDBJ

GenBank

Runx1 3D structure databases

ModBase

Runx1 Protein-protein interaction databases

STRING

Runx1 Proteomic databases

PRIDE

Runx1 Genome annotation databases

Ensembl

GeneID

KEGG

UCSC

Runx1 Organism specific databases

CTD

MGI

Runx1 Phylogenomic databases

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Runx1 Gene expression databases

Bgee

ArrayExpress

Genevestigator

Runx1 Family and domain databases

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY