| Stk4 Protein names |
| Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) |
| (MST-1) (Mammalian STE20-like protein kinase 1) |
| Stk4 Gene names |
| Stk4 (Mst1) |
| Stk4 Entry name |
| STK4_MOUSE |
| Stk4 Codon optimized cDNA Clone |
| cDNA Tag |
| cDNA Stk4 Contains A 6x histidine tag |
| Condon optimized Stk4 CDNA Formulation |
| Liquid |
| Condon optimized Stk4 CDNA Storage |
| Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw |
| Condon optimized Stk4 cDNA Applications |
| Applications: 1. Codon-optimized cDNA sequence designed for recombinant |
| protein production in both E.coli and Mammalian cell. The cDNA has been |
| cloned into E.coli expression vector with 6x Histidine tag.2. May be used as |
| RNAi assistance to restore the loss-of-function. |
| Recombinant Stk4 Protein Cat# |
| PU0316 |
| Stk4 Protein Source |
| Recombinant protein. |
| Recombinant Stk4 Protein Applications |
| Western Blot, may be used for other applications determined by user |
| Recombinant Stk4 Protein Purity |
| >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant Stk4 Protein Activity |
| N/A |
| Recombinant protein Tag |
| Recombinant Stk4 contains A 6x histidine tag |
| Recombinant Stk4 Protein Formulation |
| Liquid |
| Recombinant Stk4 Protein Storage |
| Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw |
| Stk4 Protein family |
| Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 |
| Stk4 Subcellular locations |
| Cytoplasm. Nucleus. |
| Stk4 FUNCTION (According to UniProtKB/Swiss Prot) |
| FUNCTION: Stress, pro-apoptotic kinase which, following |
| caspase-cleavage, enters the nucleus and induces chromatin condensation |
| followed by internucleosomal DNA fragmentation. Key component of the |
| Hippo signaling pathway which plays a pivotal role in organ size control and |
| tumor suppression by restricting proliferation and promoting apoptosis. The |
| core of this pathway is composed of a kinase cascade wherein MST1/MST2, |
| in complex with its regulatory protein SAV1, phosphorylates and activates |
| LATS1/2 in complex with its regulatory protein MOB1, which in turn |
| phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. |
| Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus |
| to regulate cellular genes important for cell proliferation, cell death, and |
| cell migration. MST1/MST2 are required to repress proliferation of mature |
| hepatocytes, to prevent activation of facultative adult liver stem cells (oval |
| cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone |
| H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative |
| stress, which results in its nuclear translocation and cell death initiation. |
| Stk4 3D structure databases |
| ModBase |
| Stk4 Protein-protein interaction databases |
| STRING |
| Stk4 Proteomic databases |
| PRIDE |
| Stk4 Organism specific databases |
| CTD |
MGI |
| FOR in vitro RESEARCH USE ONLY |
|
|
