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| Human cd209 (aa 59 – 404) |
| CD209 Swiss Prot | | Q9NNX6 |
| CD209 Protein names | | CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) |
| CD209 Gene names | | CD209 CLEC4L |
| Organism | | Human |
| CD209 Entry name | | CD209_HUMAN |
| CD209 Codon optimized cDNA Clone |
| CD209 cDNA Cat | | RPV0339 |
| cDNA Tag | | cDNA CD209 contains A 6x histidine tag |
| Condon optimized CD209 cDNA Formulation | | Liquid |
| Condon optimized CD209 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD209 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD209 Protein |
| Recombinant CD209 Protein Cat | | PV0339 |
| CD209 Protein Source | | Recombinant protein |
| Recombinant CD209 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD209 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD209 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD209 contains A 6x histidine tag |
| Recombinant CD209 Protein Formulation | | Liquid |
| Recombinant CD209 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD209 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD209 SUBUNIT | | SUBUNIT: Homotetramer. Binds to many viral surface glycoproteins such as HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus envelope glycoproteins, cytomegalovirus gB, HCV E2 and dengue virus major envelope protein E. |
| CD209 Subcellular locations | | SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Single-pass type II membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Single-pass type II |
| | membrane protein (Probable). ; SUBCELLULAR LOCATION: Isoform 6: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 7: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 8: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 9: |
| | Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 10: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 11: Secreted (Probable). ; SUBCELLULAR LOCATION: Isoform 12: Secreted (Probable). |
| CD209 FUNCTION According to UniProtKB Swiss Prot | | Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent |
| | manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in |
| | Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.; On DCs it is a high affinity receptor for ICAM2 and ICAM3 by |
| | binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding |
| | to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. |
| CD209 Sequence databases | | EMBL | DDBJ | GenBank |
| CD209 3D structure databases | | ModBase |
| CD209 Protein protein interaction databases | | STRING |
| CD209 Proteomic databases | | PRIDE |
| CD209 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD209 Organism specific databases | | CTD | MGI |
| CD209 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD209 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD209 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
