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Human RPS6KB1 (aa 1-525)
RPS6KB1 Swiss Prot#
P23443
RPS6KB1 Protein names
Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6

kinase I) (S6K1) (S6K) (70 kDa ribosomal protein S6 kinase 1) (p70 S6

kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha)
RPS6KB1 Gene names
RPS6KB1 (STK14A)
Organism
Human
RPS6KB1 Entry name
KS6B1_HUMAN
RPS6KB1 Codon optimized cDNA Clone
RPS6KB1 CDNA Cat#
RPT0342
cDNA Tag
cDNA RPS6KB1 Contains A 6x histidine tag
Condon optimized RPS6KB1 CDNA Formulation
Liquid
Condon optimized RPS6KB1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized RPS6KB1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant RPS6KB1 Protein
Recombinant RPS6KB1 Protein Cat#
PT0342
RPS6KB1 Protein Source
Recombinant protein.
Recombinant RPS6KB1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant RPS6KB1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant RPS6KB1 Protein Activity
N/A
Recombinant protein Tag
Recombinant RPS6KB1 contains A 6x histidine tag
Recombinant RPS6KB1 Protein Formulation
Liquid
Recombinant RPS6KB1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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RPS6KB1 Protein family
Protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase

subfamily
RPS6KB1 Subcellular locations
Cell junction > synapse > synaptosome. Mitochondrion outer membrane.

Nucleus. Cytoplasm. Cytoplasm.
RPS6KB1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Acts to integrate nutrient and growth factor signals in regulation

of protein synthesis, cell proliferation, cell growth, cell cycle progression

and cell survival. Downstream effector of the mTOR signaling pathway.

Phosphorylates specifically ribosomal protein S6 in response to insulin or

several classes of mitogens. During translation initiation, the inactive form

associatess with the eIF-3 complex under conditions of nutrient depletion.

Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-

3 complex and the free activated form can phosphorylate other translational

targets including EIF4B. Promotes protein synthesis by phosphorylating

PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR

leading to regulation of mammalian target of rapamycin complex 2 (mTORC2)

signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates

IRS1 at multiple serine residues coupled with insulin resistance; probably

phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1

degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K

activity. Phosphorylates BAD at 'Ser-99' in response to IGF1 leading to

BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates

mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex;

probably phosphorylates RMP at 'Ser-99'. The free mitochondrial PPP1CC

can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a

negative feed back mechanism for the RPS6KB1 antiapoptotic function.

Phosphorylates GSK3B at 'Ser-9' under conditions leading to loss of the

TSC1-TSC2 complex. Phosphorylates POLDIP3.
RPS6KB1 Sequence databases
EMBL DDBJ GenBank
RPS6KB1 3D structure databases
ModBase
RPS6KB1 Protein-protein interaction databases
STRING
RPS6KB1 Proteomic databases
PRIDE
RPS6KB1 Genome annotation databases
Ensembl GeneID KEGG UCSC
RPS6KB1 Organism specific databases
CTD MGI
RPS6KB1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA