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Human EYA2 (aa 1-538)
EYA2 Swiss Prot#
O00167
EYA2 Protein names
Eyes absent homolog 2 (EC 3.1.3.48)
EYA2 Gene names
EYA2 (EAB1)
Organism
Human
EYA2 Entry name
EYA2_HUMAN
EYA2 Codon optimized cDNA Clone
EYA2 CDNA Cat#
RPT0346
cDNA Tag
cDNA EYA2 Contains A 6x histidine tag
Condon optimized EYA2 CDNA Formulation
Liquid
Condon optimized EYA2 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized EYA2 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant EYA2 Protein
Recombinant EYA2 Protein Cat#
PT0346
EYA2 Protein Source
Recombinant protein.
Recombinant EYA2 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant EYA2 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant EYA2 Protein Activity
N/A
Recombinant protein Tag
Recombinant EYA2 contains A 6x histidine tag
Recombinant EYA2 Protein Formulation
Liquid
Recombinant EYA2 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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EYA2 Protein family
HAD-like hydrolase superfamily, EYA family
EYA2 Subcellular locations
Cytoplasm. Nucleus.
EYA2 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-

142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone

H2AX plays a central role in DNA repair and acts as a mark that

distinguishes between apoptotic and repair responses to genotoxic stress.

Promotes efficient DNA repair by dephosphorylating H2AX, promoting the

recruitment of DNA repair complexes containing MDC1. Its function as

histone phosphatase probably explains its role in transcription regulation

during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4

and SIX5. Together with SIX1 and DACH2 seem to be involved in

myogenesis. May be involved in development of the eye. Interaction with

GNAZ and GNAI2 prevents nuclear translocation and transcriptional

activity.
EYA2 Sequence databases
EMBL DDBJ GenBank
EYA2 3D structure databases
ModBase
EYA2 Protein-protein interaction databases
STRING
EYA2 Proteomic databases
PRIDE
EYA2 Genome annotation databases
Ensembl GeneID KEGG UCSC
EYA2 Organism specific databases
CTD MGI
EYA2 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
EYA2 Gene expression databases
Bgee ArrayExpress Genevestigator
EYA2 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY