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Rat Agt (aa 25-477)
Agt Swiss Prot#
P01015
Agt Protein names
Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin I)

(Ang I) Angiotensin-2 (Angiotensin II) (Ang II) Angiotensin-3 (Angiotensin III)

(Ang III) (Des-Asp[1]-angiotensin II)]
Agt Gene names
Agt (Serpina8)
Organism
Rat
Agt Entry name
ANGT_RAT
Agt Codon optimized cDNA Clone
Agt CDNA Cat#
RPU0358
cDNA Tag
cDNA Agt Contains A 6x histidine tag
Condon optimized Agt CDNA Formulation
Liquid
Condon optimized Agt CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Agt cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Agt Protein
Recombinant Agt Protein Cat#
PU0358
Agt Protein Source
Recombinant protein.
Recombinant Agt Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Agt Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Agt Protein Activity
N/A
Recombinant protein Tag
Recombinant Agt contains A 6x histidine tag
Recombinant Agt Protein Formulation
Liquid
Recombinant Agt Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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Agt Protein family
Serpin family
Agt Subcellular locations
Secreted.
Agt FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Essential component of the renin-angiotensin system (RAS), a

potent regulator of blood pressure, body fluid and electrolyte homeostasis

(By similarity). In response to lowered blood pressure, the enzyme renin

cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10) (By

similarity). Angiotensin-1 is a substrate of ACE (angiotensin converting

enzyme) that removes a dipeptide to yield the physiologically active peptide

angiotensin-2 (angiotensin 1-8) (By similarity). Angiotensin-1 and

angiotensin-2 can be further processed to generate angiotensin-3

(angiotensin 2-8), angiotensin-4 (angiotensin 3-8) (By similarity). Angiotensin

1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME

(neprilysin) (By similarity). Angiotensin 1-9 is cleaved from angiotensin-1 by

ACE2 (By similarity).; FUNCTION: Angiotensin-2 acts directly on vascular

smooth muscle as a potent vasoconstrictor, affects cardiac contractility and

heart rate through its action on the sympathetic nervous system, and alters

renal sodium and water absorption through its ability to stimulate the zona

glomerulosa cells of the adrenal cortex to synthesize and secrete

aldosterone (By similarity).; FUNCTION: Angiotensin-3 stimulates

aldosterone release (By similarity).; FUNCTION: Angiotensin 1-7 is a ligand

for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and

antidiuretic effects (By similarity). Has an antithrombotic effect that

involves MAS1-mediated release of nitric oxide from platelets.
Agt Sequence databases
EMBL DDBJ GenBank
Agt 3D structure databases
ModBase
Agt Protein-protein interaction databases
STRING
Agt Proteomic databases
PRIDE
Agt Genome annotation databases
Ensembl GeneID KEGG UCSC
Agt Organism specific databases
CTD MGI
Agt Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Agt Gene expression databases
Bgee ArrayExpress Genevestigator
Agt Family and domain databases
InterPro PROSITE ProtoNet