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| Mouse cd22 (aa 22 – 422) |
| CD22 Swiss Prot | | P35329 |
| CD22 Protein names | | B-cell receptor CD22 (B-lymphocyte cell adhesion molecule) (BL-CAM) (Sialic acid-binding Ig-like lectin 2) (Siglec-2) (T-cell surface antigen Leu-14) (CD antigen CD22) |
| CD22 Gene names | | Cd22 Lyb-8 Siglec2 |
| Organism | | Mouse |
| CD22 Entry name | | CD22_MOUSE |
| CD22 Codon optimized cDNA Clone |
| CD22 cDNA Cat | | RPV0361 |
| cDNA Tag | | cDNA CD22 contains A 6x histidine tag |
| Condon optimized CD22 cDNA Formulation | | Liquid |
| Condon optimized CD22 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD22 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD22 Protein |
| Recombinant CD22 Protein Cat | | PV0361 |
| CD22 Protein Source | | Recombinant protein |
| Recombinant CD22 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD22 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD22 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD22 contains A 6x histidine tag |
| Recombinant CD22 Protein Formulation | | Liquid |
| Recombinant CD22 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD22 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD22 SUBUNIT | | SUBUNIT: Interacts with SYK, PIK3R1/PIK3R2, PLCG1, SHC1, INPP5D and GRB2 upon phosphorylation. May form a complex with INPP5D/SHIP, GRB2 and SHC1. Interacts with PTPN6/SHP-1 upon phosphorylation (By similarity). |
| CD22 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. |
| CD22 FUNCTION According to UniProtKB Swiss Prot | | Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive |
| | regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling |
| | molecules. |
| CD22 Sequence databases | | EMBL | DDBJ | GenBank |
| CD22 3D structure databases | | ModBase |
| CD22 Protein protein interaction databases | | STRING |
| CD22 Proteomic databases | | PRIDE |
| CD22 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD22 Organism specific databases | | CTD | MGI |
| CD22 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD22 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD22 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
