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Rat Casp3 (aa 1-277)
Casp3 Swiss Prot#
P55213
Casp3 Protein names
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32)

(CPP-32) (Yama protein) (SREBP cleavage activity 1) (SCA-1) (LICE) (IRP)

[Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Casp3 Gene names
Casp3 (Cpp32)
Organism
Rat
Casp3 Entry name
CASP3_RAT
Casp3 Codon optimized cDNA Clone
Casp3 CDNA Cat#
RPU0364
cDNA Tag
cDNA Casp3 Contains A 6x histidine tag
Condon optimized Casp3 CDNA Formulation
Liquid
Condon optimized Casp3 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized Casp3 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant Casp3 Protein
Recombinant Casp3 Protein Cat#
PU0364
Casp3 Protein Source
Recombinant protein.
Recombinant Casp3 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant Casp3 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant Casp3 Protein Activity
N/A
Recombinant protein Tag
Recombinant Casp3 contains A 6x histidine tag
Recombinant Casp3 Protein Formulation
Liquid
Recombinant Casp3 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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Casp3 Protein family
Peptidase C14A family
Casp3 Subcellular locations
Cytoplasm.
Casp3 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Involved in the activation cascade of caspases responsible for

apoptosis execution. At the onset of apoptosis it proteolytically cleaves

poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves

and activates sterol regulatory element binding proteins (SREBPs) between

the basic helix-loop-helix leucine zipper domain and the membrane

attachment domain. Cleaves and activates caspase-6, -7 and -9 (By

similarity).
Casp3 Sequence databases
EMBL DDBJ GenBank
Casp3 3D structure databases
ModBase
Casp3 Protein-protein interaction databases
STRING
Casp3 Proteomic databases
PRIDE
Casp3 Genome annotation databases
Ensembl GeneID KEGG UCSC
Casp3 Organism specific databases
CTD MGI
Casp3 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Casp3 Gene expression databases
Bgee ArrayExpress Genevestigator
Casp3 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY