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| Human cd227 (aa 921 –1158) |
| CD227 Swiss Prot | | P15941 |
| CD227 Protein names | | Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Carcinoma-associated mucin) (Episialin) (H23AG) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)] |
| CD227 Gene names | | Muc1 Muc-1 |
| Organism | | Human |
| CD227 Entry name | | MUC1_HUMAN |
| CD227 Codon optimized cDNA Clone |
| CD227 cDNA Cat | | RPV0372 |
| cDNA Tag | | cDNA CD227 contains A 6x histidine tag |
| Condon optimized CD227 cDNA Formulation | | Liquid |
| Condon optimized CD227 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD227 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD227 Protein |
| Recombinant CD227 Protein Cat | | PV0372 |
| CD227 Protein Source | | Recombinant protein |
| Recombinant CD227 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD227 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD227 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD227 contains A 6x histidine tag |
| Recombinant CD227 Protein Formulation | | Liquid |
| Recombinant CD227 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD227 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD227 SUBUNIT | | SUBUNIT: The alpha subunit forms a tight, non-covalent heterodimeric complex with the proteolytically-released beta-subunit. Interaction, via the tandem repeat region, with domain 1 of ICAM1 is implicated in cell migration and metastases. Isoform 1 binds directly the SH2 domain of GRB2, and forms a MUC1/GRB2/SOS1 complex involved in RAS signaling. The cytoplasmic tail (MUC1CT) interacts with several proteins such as SRC, CTNNB1 and ERBs. Interaction with the SH2 domain of |
| | CSK decreases interaction with GSK3B. Interacts with CTNNB1/beta-catenin and JUP/gamma-catenin and promotes cell adhesion. Interaction with JUP/gamma-catenin is induced by heregulin. Binds PRKCD, ERBB2, ERBB3 and ERBB4. Heregulin (HRG) |
| | stimulates the interaction with ERBB2 and, to a much lesser extent, the interaction with ERBB3 and ERBB4. Interacts with P53 in response to DNA damage. Interacts with KLF4. Interacts with estrogen receptor alpha/ESR1, through its DNA-binding |
| | domain, and stimulates its transcription activity. Binds ADAM17. |
| CD227 Subcellular locations | | SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I membrane protein. Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions.; SUBCELLULAR LOCATION: Isoform 5: Secreted. ; SUBCELLULAR LOCATION: Isoform 7: Secreted. ; SUBCELLULAR LOCATION: Isoform 9: Secreted. ; SUBCELLULAR |
| | LOCATION: Mucin-1 subunit beta: Cell membrane. Cytoplasm. Nucleus. Note=On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, |
| | colocalizes with JUP/gamma-catenin at the nucleus. |
| CD227 FUNCTION According to UniProtKB Swiss Prot | | The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes |
| | tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
| CD227 Sequence databases | | EMBL | DDBJ | GenBank |
| CD227 3D structure databases | | ModBase |
| CD227 Protein protein interaction databases | | STRING |
| CD227 Proteomic databases | | PRIDE |
| CD227 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD227 Organism specific databases | | CTD | MGI |
| CD227 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD227 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD227 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
