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| Human cd26 (aa 29 – 429) |
| CD26 Swiss Prot | | P27487 |
| CD26 Protein names | | Dipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)] |
| CD26 Gene names | | DPP4 ADCP2 CD26 |
| Organism | | Human |
| CD26 Entry name | | DPP4_HUMAN |
| CD26 Codon optimized cDNA Clone |
| CD26 cDNA Cat | | RPV0427 |
| cDNA Tag | | cDNA CD26 contains A 6x histidine tag |
| Condon optimized CD26 cDNA Formulation | | Liquid |
| Condon optimized CD26 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD26 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD26 Protein |
| Recombinant CD26 Protein Cat | | PV0427 |
| CD26 Protein Source | | Recombinant protein |
| Recombinant CD26 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD26 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD26 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD26 contains A 6x histidine tag |
| Recombinant CD26 Protein Formulation | | Liquid |
| Recombinant CD26 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD26 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD26 SUBUNIT | | SUBUNIT: Monomer. Homodimer or heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. |
| | Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is |
| | direct. Interacts with GPC3. |
| CD26 Subcellular locations | | SUBCELLULAR LOCATION: Dipeptidyl peptidase 4 soluble form: Secreted. Note=Detected in the serum and the seminal fluid.; SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell projection, invadopodium membrane; Single-pass type II membrane protein. Cell projection, lamellipodium membrane; Single-pass type II membrane protein. Cell junction. Membrane raft. Note=Translocated to the |
| | apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its |
| | interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. |
| | Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R |
| | in internalized cytoplasmic vesicles adjacent to the cell surface. |
| CD26 FUNCTION According to UniProtKB Swiss Prot | | Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the |
| | pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When |
| | overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many |
| | chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
| CD26 Sequence databases | | EMBL | DDBJ | GenBank |
| CD26 3D structure databases | | ModBase |
| CD26 Protein protein interaction databases | | STRING |
| CD26 Proteomic databases | | PRIDE |
| CD26 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD26 Organism specific databases | | CTD | MGI |
| CD26 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD26 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD26 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
