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| Human CD284 (aa 24 – 426) |
| CD284 Swiss Prot | | O00206 |
| CD284 Protein names | | Toll-like receptor 4 (hToll) (CD antigen CD284) |
| CD284 Gene names | | TLR4 |
| Organism | | Human |
| CD284 Entry name | | TLR4_HUMAN |
| CD284 Codon optimized cDNA Clone |
| CD284 cDNA Cat | | RPV0483 |
| cDNA Tag | | cDNA CD284 contains A 6x histidine tag |
| Condon optimized CD284 cDNA Formulation | | Liquid |
| Condon optimized CD284 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD284 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD284 Protein |
| Recombinant CD284 Protein Cat | | PV0483 |
| CD284 Protein Source | | Recombinant protein |
| Recombinant CD284 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD284 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD284 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD284 contains A 6x histidine tag |
| Recombinant CD284 Protein Formulation | | Liquid |
| Recombinant CD284 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD284 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD284 SUBUNIT | | SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via their respective TIR domains. Interacts with NOX4. Interacts with CNPY3 (By similarity). |
| CD284 Subcellular locations | | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| CD284 FUNCTION According to UniProtKB Swiss Prot | | Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. |
| CD284 Sequence databases | | EMBL | DDBJ | GenBank |
| CD284 3D structure databases | | ModBase |
| CD284 Protein protein interaction databases | | STRING |
| CD284 Proteomic databases | | PRIDE |
| CD284 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD284 Organism specific databases | | CTD | MGI |
| CD284 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD284 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD284 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
