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| Mouse cd295 (aa 637 – 729) |
| CD295 Swiss Prot | | P48356 |
| CD295 Protein names | | Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295) |
| CD295 Gene names | | Lepr Db Obr |
| Organism | | Mouse |
| CD295 Entry name | | LEPR_MOUSE |
| CD295 Codon optimized cDNA Clone |
| CD295 cDNA Cat | | RPV0504 |
| cDNA Tag | | cDNA CD295 contains A 6x histidine tag |
| Condon optimized CD295 cDNA Formulation | | Liquid |
| Condon optimized CD295 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD295 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD295 Protein |
| Recombinant CD295 Protein Cat | | PV0504 |
| CD295 Protein Source | | Recombinant protein |
| Recombinant CD295 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD295 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD295 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD295 contains A 6x histidine tag |
| Recombinant CD295 Protein Formulation | | Liquid |
| Recombinant CD295 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD295 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD295 SUBUNIT | | SUBUNIT: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3. Interaction with SOCS3 inhibits JAK/STAT signaling. |
| CD295 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. ; SUBCELLULAR LOCATION: Isoform E: Secreted (Probable). |
| CD295 FUNCTION According to UniProtKB Swiss Prot | | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.; Isoform A may act to transport leptin to the cerebrospinal fluid (By similarity).; Isoform E could function as a transport protein. |
| CD295 Sequence databases | | EMBL | DDBJ | GenBank |
| CD295 3D structure databases | | ModBase |
| CD295 Protein protein interaction databases | | STRING |
| CD295 Proteomic databases | | PRIDE |
| CD295 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD295 Organism specific databases | | CTD | MGI |
| CD295 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD295 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD295 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
