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| Mouse CD305 (aa 22 – 144) |
| CD305 Swiss Prot | | Q8BG84 |
| CD305 Protein names | | Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (mLAIR1) (CD antigen CD305) |
| CD305 Gene names | | Lair1 |
| Organism | | Mouse |
| CD305 Entry name | | LAIR1_MOUSE |
| CD305 Codon optimized cDNA Clone |
| CD305 cDNA Cat | | RPV0550 |
| cDNA Tag | | cDNA CD305 contains A 6x histidine tag |
| Condon optimized CD305 cDNA Formulation | | Liquid |
| Condon optimized CD305 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD305 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD305 Protein |
| Recombinant CD305 Protein Cat | | PV0550 |
| CD305 Protein Source | | Recombinant protein |
| Recombinant CD305 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD305 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD305 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD305 contains A 6x histidine tag |
| Recombinant CD305 Protein Formulation | | Liquid |
| Recombinant CD305 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD305 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD305 SUBUNIT | | SUBUNIT: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK (By similarity). |
| CD305 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). |
| CD305 FUNCTION According to UniProtKB Swiss Prot | | Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, |
| | downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in |
| | myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells |
| | (By similarity). |
| CD305 Sequence databases | | EMBL | DDBJ | GenBank |
| CD305 3D structure databases | | ModBase |
| CD305 Protein protein interaction databases | | STRING |
| CD305 Proteomic databases | | PRIDE |
| CD305 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD305 Organism specific databases | | CTD | MGI |
| CD305 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD305 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD305 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
