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| Human cd31 (aa 28 – 601) |
| CD31 Swiss Prot | | P16284 |
| CD31 Protein names | | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) |
| CD31 Gene names | | PECAM1 |
| Organism | | Human |
| CD31 Entry name | | PECA1_HUMAN |
| CD31 Codon optimized cDNA Clone |
| CD31 cDNA Cat | | RPV0557 |
| cDNA Tag | | cDNA CD31 contains A 6x histidine tag |
| Condon optimized CD31 cDNA Formulation | | Liquid |
| Condon optimized CD31 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD31 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD31 Protein |
| Recombinant CD31 Protein Cat | | PV0557 |
| CD31 Protein Source | | Recombinant protein |
| Recombinant CD31 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD31 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD31 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD31 contains A 6x histidine tag |
| Recombinant CD31 Protein Formulation | | Liquid |
| Recombinant CD31 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD31 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD31 SUBUNIT | | SUBUNIT: Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. |
| CD31 Subcellular locations | | SUBCELLULAR LOCATION: Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.; SUBCELLULAR LOCATION: Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. |
| CD31 FUNCTION According to UniProtKB Swiss Prot | | Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by |
| | transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the |
| | viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together |
| | with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. |
| | Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). |
| CD31 Sequence databases | | EMBL | DDBJ | GenBank |
| CD31 3D structure databases | | ModBase |
| CD31 Protein protein interaction databases | | STRING |
| CD31 Proteomic databases | | PRIDE |
| CD31 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD31 Organism specific databases | | CTD | MGI |
| CD31 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD31 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD31 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
