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Magnetic Separator
Magnetic Beads and Applications
Affinity Magnetic Beads
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Antibody Purification & IP
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Antibody Immobilization
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Recombinant Protein
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Human PRPF19 (aa 2-504)
PRPF19 Swiss Prot#
Q9UMS4
PRPF19 Protein names
Pre-mRNA-processing factor 19 (PRP19/PSO4 homolog) (hPso4) (Nuclear

matrix protein 200) (Senescence evasion factor)
PRPF19 Gene names
PRPF19 (NMP200) (PRP19) (SNEV)
Organism
Human
PRPF19 Entry name
PRP19_HUMAN
PRPF19 Codon optimized cDNA Clone
PRPF19 CDNA Cat#
RPR0581
cDNA Tag
cDNA PRPF19 Contains A 6x histidine tag
Condon optimized PRPF19 CDNA Formulation
Liquid
Condon optimized PRPF19 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized PRPF19 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant PRPF19 Protein
Recombinant PRPF19 Protein Cat#
PR0581
PRPF19 Protein Source
Recombinant protein.
Recombinant PRPF19 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant PRPF19 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant PRPF19 Protein Activity
N/A
Recombinant protein Tag
Recombinant PRPF19 contains A 6x histidine tag
Recombinant PRPF19 Protein Formulation
Liquid
Recombinant PRPF19 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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PRPF19 Protein family
WD repeat PRP19 family
PRPF19 Subcellular locations
Nucleus. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle.
PRPF19 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Plays a role in DNA double-strand break (DSB) repair and pre-

mRNA splicing reaction. Binds double-stranded DNA in a sequence-

nonspecific manner. Acts as a structural component of the nuclear

framework. May also serve as a support for spliceosome binding and

activity. Essential for spliceosome assembly in a oligomerization-dependent

manner and might also be important for spliceosome stability. May have E3

ubiquitin ligase activity. The PSO4 complex is required in the DNA

interstrand cross-links (ICLs) repair process. Overexpression of PRPF19

might extend the cellular life span by increasing the resistance to stress or

by improving the DNA repair capacity of the cells.
PRPF19 Sequence databases
EMBL DDBJ GenBank
PRPF19 3D structure databases
ModBase
PRPF19 Protein-protein interaction databases
STRING
PRPF19 Proteomic databases
PRIDE
PRPF19 Genome annotation databases
Ensembl GeneID KEGG UCSC
PRPF19 Organism specific databases
CTD MGI
PRPF19 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
PRPF19 Gene expression databases
Bgee ArrayExpress Genevestigator
PRPF19 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY