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| Human cd324 (aa 155 – 709) |
| CD324 Swiss Prot | | P12830 |
| CD324 Protein names | | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] |
| CD324 Gene names | | CDH1 CDHE UVO |
| Organism | | Human |
| CD324 Entry name | | CADH1_HUMAN |
| CD324 Codon optimized cDNA Clone |
| CD324 cDNA Cat | | RPV0591 |
| cDNA Tag | | cDNA CD324 contains A 6x histidine tag |
| Condon optimized CD324 cDNA Formulation | | Liquid |
| Condon optimized CD324 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD324 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD324 Protein |
| Recombinant CD324 Protein Cat | | PV0591 |
| CD324 Protein Source | | Recombinant protein |
| Recombinant CD324 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD324 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD324 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD324 contains A 6x histidine tag |
| Recombinant CD324 Protein Formulation | | Liquid |
| Recombinant CD324 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD324 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD324 SUBUNIT | | SUBUNIT: Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as |
| | LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with |
| | CAV1. Interacts with the TRPV4 and CTNNB1 complex (By similarity). |
| CD324 Subcellular locations | | SUBCELLULAR LOCATION: Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with |
| | RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. |
| CD324 FUNCTION According to UniProtKB Swiss Prot | | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. |
| | Has a strong inhibitory effect on APP C99 and C83 production. |
| CD324 Sequence databases | | EMBL | DDBJ | GenBank |
| CD324 3D structure databases | | ModBase |
| CD324 Protein protein interaction databases | | STRING |
| CD324 Proteomic databases | | PRIDE |
| CD324 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD324 Organism specific databases | | CTD | MGI |
| CD324 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD324 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD324 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
