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Human ICOS (aa 21-199)
ICOS Swiss Prot#
Q9Y6W8
ICOS Protein names
Inducible T-cell costimulator (Activation-inducible lymphocyte

immunomediatory molecule) (CD antigen CD278)
ICOS Gene names
ICOS (AILIM)
Organism
Human
ICOS Entry name
ICOS_HUMAN
ICOS Codon optimized cDNA Clone
ICOS CDNA Cat#
RPU0060
cDNA Tag
cDNA ICOS Contains A 6x histidine tag
Condon optimized ICOS CDNA Formulation
Liquid
Condon optimized ICOS CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized ICOS cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant ICOS Protein

Recombinant ICOS Protein Cat#
PU0060
ICOS Protein Source
Recombinant protein.
Recombinant ICOS Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ICOS Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ICOS Protein Activity
N/A
Recombinant protein Tag
Recombinant ICOS contains A 6x histidine tag
Recombinant ICOS Protein Formulation
Liquid
Recombinant ICOS Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Place Order for Recombinant ICOS Protein or cDNA
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ICOS Protein family
-
ICOS Subcellular locations
Cell membrane; Single-pass type I membrane protein. Secreted.
ICOS FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: Enhances all basic T-cell responses to a foreign antigen, namely

proliferation, secretion of lymphokines, up-regulation of molecules that

mediate cell-cell interaction, and effective help for antibody secretion by B-

cells. Essential both for efficient interaction between T and B-cells and for

normal antibody responses to T-cell dependent antigens. Does not up-

regulate the production of interleukin-2, but superinduces the synthesis of

interleukin-10. Prevents the apoptosis of pre T-cells. Plays a

critical role in CD40-mediated class switching of immunoglobin isotypes (By

similarity).
ICOS Sequence databases
EMBL DDBJ GenBank
ICOS 3D structure databases
ModBase
ICOS Protein-protein interaction databases
STRING
ICOS Proteomic databases
PRIDE
ICOS Genome annotation databases
Ensembl GeneID KEGG UCSC
ICOS Organism specific databases
CTD MGI
ICOS Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
ICOS Gene expression databases
Bgee ArrayExpress Genevestigator
ICOS Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY