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Human ASNA1 (aa 1-348)
ASNA1 Swiss Prot#
O43681
ASNA1 Protein names
Arsenical pump-driving ATPase (EC 3.6.3.16) (Arsenite-translocating

ATPase) (Arsenical resistance ATPase) (Arsenite-transporting ATPase)
ASNA1 Gene names
ASNA1 (ARSA)
Organism
Human
ASNA1 Entry name
ASNA_HUMAN
ASNA1 Codon optimized cDNA Clone
ASNA1 CDNA Cat#
RPR0062
cDNA Tag
cDNA ASNA1 Contains A 6x histidine tag
Condon optimized ASNA1 CDNA Formulation
Liquid
Condon optimized ASNA1 CDNA Storage
Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
Condon optimized ASNA1 cDNA Applications
Applications: 1. Codon-optimized cDNA sequence designed for recombinant

protein production in both E.coli and Mammalian cell. The cDNA has been

cloned into E.coli expression vector with 6x Histidine tag.2. May be used as

RNAi assistance to restore the loss-of-function.

Recombinant ASNA1 Protein

Recombinant ASNA1 Protein Cat#
PR0062
ASNA1 Protein Source
Recombinant protein.
Recombinant ASNA1 Protein Applications
Western Blot, may be used for other applications determined by user
Recombinant ASNA1 Protein Purity
>90%, as determined by SDS-PAGE under reducing conditions
Recombinant ASNA1 Protein Activity
N/A
Recombinant protein Tag
Recombinant ASNA1 contains A 6x histidine tag
Recombinant ASNA1 Protein Formulation
Liquid
Recombinant ASNA1 Protein Storage
Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw
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ASNA1 Protein family
ArsA ATPase family
ASNA1 Subcellular locations
Cytoplasm. Endoplasmic reticulum. Nucleus > nucleolus.
ASNA1 FUNCTION (According to UniProtKB/Swiss Prot)
FUNCTION: ATPase required for the post-translational delivery of tail-

anchored (TA) proteins to the endoplasmic reticulum. Recognizes and

selectively binds the transmembrane domain of TA proteins in the cytosol.

This complex then targets to the endoplasmic reticulum by membrane-bound

receptors, where the tail-anchored protein is released for insertion. This

process is regulated by ATP binding and hydrolysis. ATP binding drives the

homodimer towards the closed dimer state, facilitating recognition of newly

synthesized TA membrane proteins. ATP hydolysis is required for insertion.

Subsequently, the homodimer reverts towards the open dimer state,

lowering its affinity for the membrane-bound receptor, and returning it to the

cytosol to initiate a new round of targeting (By similarity). May be involved in

insulin signaling.
ASNA1 Sequence databases
EMBL DDBJ GenBank
ASNA1 3D structure databases
ModBase
ASNA1 Protein-protein interaction databases
STRING
ASNA1 Proteomic databases
PRIDE
ASNA1 Genome annotation databases
Ensembl GeneID KEGG UCSC
ASNA1 Organism specific databases
CTD MGI
ASNA1 Phylogenomic databases
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
ASNA1 Gene expression databases
Bgee ArrayExpress Genevestigator
ASNA1 Family and domain databases
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY