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| Human cd4 (aa 26 – 396) |
| CD4 Swiss Prot | | P01730 |
| CD4 Protein names | | T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4) |
| CD4 Gene names | | CD4 |
| Organism | | Human |
| CD4 Entry name | | CD4_HUMAN |
| CD4 Codon optimized cDNA Clone |
| CD4 cDNA Cat | | RPV0687 |
| cDNA Tag | | cDNA CD4 contains A 6x histidine tag |
| Condon optimized CD4 cDNA Formulation | | Liquid |
| Condon optimized CD4 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD4 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD4 Protein |
| Recombinant CD4 Protein Cat | | PV0687 |
| CD4 Protein Source | | Recombinant protein |
| Recombinant CD4 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD4 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD4 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD4 contains A 6x histidine tag |
| Recombinant CD4 Protein Formulation | | Liquid |
| Recombinant CD4 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD4 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD4 SUBUNIT | | SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. |
| CD4 Subcellular locations | | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
| CD4 FUNCTION According to UniProtKB Swiss Prot | | Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. |
| CD4 Sequence databases | | EMBL | DDBJ | GenBank |
| CD4 3D structure databases | | ModBase |
| CD4 Protein protein interaction databases | | STRING |
| CD4 Proteomic databases | | PRIDE |
| CD4 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD4 Organism specific databases | | CTD | MGI |
| CD4 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD4 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD4 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
