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| Human cd46 (aa 35 – 343) |
| CD46 Swiss Prot | | P15529 |
| CD46 Protein names | | Membrane cofactor protein (TLX) (Trophoblast leukocyte common antigen) (CD antigen CD46) |
| CD46 Gene names | | CD46 MCP MIC10 |
| Organism | | Human |
| CD46 Entry name | | MCP_HUMAN |
| CD46 Codon optimized cDNA Clone |
| CD46 cDNA Cat | | RPV0711 |
| cDNA Tag | | cDNA CD46 contains A 6x histidine tag |
| Condon optimized CD46 cDNA Formulation | | Liquid |
| Condon optimized CD46 cDNA Storage | | Ship at Room temperature. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Condon optimized CD46 cDNA Applications | | Applications: 1. Codon-optimized cDNA sequence designed for recombinant protein production in both E.coli and Mammalian cell. The cDNA has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss of function. |
| Recombinant CD46 Protein |
| Recombinant CD46 Protein Cat | | PV0711 |
| CD46 Protein Source | | Recombinant protein |
| Recombinant CD46 Protein Applications | | Western Blot, may be used for other applications determined by user |
| Recombinant CD46 Protein Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Recombinant CD46 Protein Activity | | N/A |
| Recombinant protein Tag | | Recombinant CD46 contains A 6x histidine tag |
| Recombinant CD46 Protein Formulation | | Liquid |
| Recombinant CD46 Protein Storage | | Ship at 4℃. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant CD46 Protein or cDNA | | For pricing and availability, Click Here >>> |
| CD46 SUBUNIT | | SUBUNIT: Interacts with C3b and C4b. Binds to Measles virus H protein, to Human herpesvirus 6 GH protein and to human adenovirus B/D PIV/fiber protein, and acts as a receptor for these viruses. Binds to Streptococcus pyogenes M protein and to type IV pili from Neisseria, and may act as a receptor for these pathogenic bacteria. |
| CD46 Subcellular locations | | SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide. |
| CD46 FUNCTION According to UniProtKB Swiss Prot | | Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are |
| | thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. |
| CD46 Sequence databases | | EMBL | DDBJ | GenBank |
| CD46 3D structure databases | | ModBase |
| CD46 Protein protein interaction databases | | STRING |
| CD46 Proteomic databases | | PRIDE |
| CD46 Genome annotation databases | | Ensembl | GeneID | KEGG | UCSC |
| CD46 Organism specific databases | | CTD | MGI |
| CD46 Phylogenomic databases | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| CD46 Gene expression databases | | Bgee | ArrayExpress | Genevestigator |
| CD46 Family and domain databases | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
